EBF Focus

Future-proofing Bioanalysis - Contributing to a sustainable world

The meeting will be organised simultaneously in
different regions on 24 and 25 September 2020 combined with a live streaming
– see TRAVEL AND LOCATION for more information


The 6th YSS will be organised simultaneously at different sites in different regions, covering all regions which young scientists could reasonably reach by train/car/local travel. The regions we identified are: UK-North, UK-Mid/South, Benelux, Italy, Switzerland/South-Germany, Rest-of-Germany, Denmark/Sweden and Spain/South of France. This spread should facilitate young scientists to travel locally to the meeting and still benefit from face to face interactions as good and safe as possible.  We keep our fingers crossed that young scientists from other regions could still be allowed to travel to one of above regions. Alternatively, they could join (part of) the meeting via live streaming.

Agenda, version 28 May 2020 – all times are CET (Brussels time zone)


24 September 2020
11:30 13:00   If local site can host 2 days: a local welcome
13:00 13:15   Welcome – coming online
13:15 14:00   Session 1: Is non-standard the new standard?
13:15 13:30   Connor Walker (Arcinova)
      Non-standard technique in a regulated environment:  what considerations come with it?
13:30 13:45   Salvatore Calogero (Swiss BioQuant)
      FACS in the bioanalysis 
13:45 14:00   Eugenia Hoffmann (F. Hoffmann-La Roche)
      Impact of drug/anti-drug antibody complexes on drug pharmacokinetics: advanced bioanalysis for a better understanding of immunogenicity
      Parallel session
14:30 15:45   Parallel Session 2: Rethinking Matrix
14:30 14:45   Michele Protti (Unibo)
      Unraveling details and potentials of VAMS technique: towards the raise of a new golden standard
14:45 15:00   Camilla Marasca (Unibo)
      Novel microfluidic-based sampling for therapeutic drug monitoring of patients under treatment with the antidepressant drug vortioxetine
15:00 15:15   Virginia Brighenti (University of Modena and Reggio Emilia)
      New Analytical Tools for the Study of Bioactive Polyphenols in Prunus avium L. (sweet cherry) and Evaluation of their Anti-oxidant Activity on an In vivo Model.
15:15 15:30   Maaike Bruin (The Netherlands Cancer Institute (NKI))
      Development and validation of an LC-MS/MS method with a broad linear dynamic range utilizing natural isotopologue transitions for quantification of tivozanib 
15:30 15:45   Jana Verstraete (UGent)
      The simultaneous quantification of thiamine, its phosphate derivatives and precursors in Arabidopsis thaliana: validation and application.
14:30 15:45   Parallel Session 3: ADApting
14:30 14:45   Hannah Craig (Covance)
      Biosimilar ADA assessments using the Gyrolab platform
14:45 15:00   Fanni Suomi (Syrinx Bioanalytics)
      Concentration analysis and immunogenicity testing of next generation oligonucleotides and targeted delivery molecules
15:00 15:15   Cara Gunning (Charles River Laboratories)
      Approaches to Improve Drug Tolerance in Immunogenicity Assays
15:15 15:30   Zoe Whiffen (LGC)
      Anti-PEG: past, present and future difficulties in a regulated environment
15:30 15:45   Adam Williams (AstraZeneca)
      Development of a method for detection of anti-drug antibodies against the PEG component of a lipid nanoparticle drug product
16:30 17:30   Session 4: Before we digest….let’s digest.
16:30 16:45   Bas Sleumer (PRA Health Sciences)
      The differences between digested and intact protein analysis: determination of somatropin in rat plasma.
16:45 17:00   Lisa Delahaye (UGent)
      Determination of paracetamol-albumin adducts via LC-HRMS
17:00 17:15   Matthew Franklin (Thermo Fisher Scientific)
      Changing up protein digestion during sample preparation to improve protein quantitation from the very beginning
17:15 17:30   Terence Hetzel (Bayer)
      Determination of thorium-conjugated monoclonal antibody from monkey plasma by different LC-MS technologies
17:30     for those staying overnight – enjoy the evening whilst keeping social distance
25 September 2020
09:00 10:30   Site dependent local activities
10:30 12:00   Science Café: A Sustainable Future
      Format: round table
      During this session we want to engage you how we can contribute to a sustainable future.
      This includes e.g. stimulating or applying the 3Rs (Replacement, Reduction and Refinement) and/or the principles of green lab/chemistry…
      We are preparing a dynamic round table discussion where all of you can contribute.
12:30 13:30   Interactive poster viewing
13:45 14:15   Pleanra Feedback from local Science Café round tables: A Sustainable Future
14:30 15:45   Session 5: It’s what’s inside that counts
14:30 14:45   Coral Munday (LGC)
      Fit-for-Purpose Validation: A Non-Standard Approach for a Non-Standard Biomarker Assay
14:45 15:00   Mondanelli Giada (University of Perugia)
      Indoleamine 2,3-dioxygenase 2 as new biomarker of tumor progression
15:00 15:15   Malleswari Challagundla (AbbVie)
      Development and validation of alpha-synuclein aggregation assay using surrogate matrix
15:15 15:30   Tessa McDonald (Unilabs York Bioanalytical Solutions)
      Qualifying the measurement of endogenous and synthetic spiked pharmacodynamic biomarker in matrix, in the presence of drug
16:00 17:15   Session 6:  Compete to Collaborate!
16:00 16:15   Rebecca Taylor (Covance)
      Investigating generic PK methods of quantifying human monoclonal antibodies in pre-clinical species by LC-MS and ligand-binding assays. 
16:15 16:30   Chris Williams (QPS Netherlands)
      Hybrid LC-MS ligand binding assays for bioanalysis
16:30 16:45   Rebecca Paterson (Charles River Laboratories)
      Antibody Drug Conjugate Bioanalysis – An opportunity for LBA and LC-MS Synergy?
16:45 17:00   Closing Remarks and Adjourn